Wednesday, 12 October 2011

fat virus


BBC story about a new kind of virus.

The largest virus yet discovered has been isolated from ocean water pulled up off the coast of Chile.

Isolation is cruel. Kids know that when they are five, scientists.

Called Megavirus chilensis, it is 10 to 20 times wider than the average virus.

So you isolated a virus which probably already has pretty serious issues? I hope you feel good about yourselves. I bet you look fat to a virus.

It just beats the previous record holder, Mimivirus, which was found in a water cooling tower in the UK in 1992.

Wait. I'm getting more of a grip on this story now. Are we saying some dago virus has beaten a British record-holder? I'm not certain about anything, I'm just saying, but drugs?

Scientists tell the journal PNAS that Megavirus probably infects amoebas, single-celled organisms that are floating free in the sea.

1. Scientists will say anything.
2. I wish I were floating free in the sea.

The particle measures about 0.7 micrometres (thousandths of a millimetre) in diameter. "It is bigger than some bacteria," explained Prof Jean-Michel Claverie, from Aix-Marseille University, Marseille, France.

Yeah? Well what Jean-Michel doesn't know is some bacteria are pretty small.

"You don't need an electron microscope to see it; you can see it with an ordinary light microscope," he told BBC News.

No, I can't.

Viruses cannot copy themselves; they need to invade a host cell if they want to replicate.

I have friends like this.

Like Mimivirus, Megavirus has hair-like structures, or fibrils, on the exterior of its shell, or capsid, that probably attract unsuspecting amoebas looking to prey on bacteria displaying similar features.

What kind of amoeba doesn't suspect a megavirus with hair-like fibrils? I would and the megavirus isn't interested in me. At some point, people and amoebas have to take responsibility for their own mistakes. Look at the banking crisis.

A study of the giant virus's DNA shows it to have more than a thousand genes, the biochemical instructions it uses to build the systems it requires to replicate once inside its host.

I went out with someone who had a thousand genes once, in a walk in wardrobe.

In the lab experiments conducted by Professor Claverie and colleagues, in which they infected fresh-water amoebas, Megavirus was seen to construct large trojan organelles - the "cells within cells" that would produce new viruses to infect other amoebas. "Everything is initiated from a single particle, and then grows and grows to become this virion factory," explained Prof Claverie. "That's why it needs all these genes."

I once went to a Virion factory. I had never realised that this was how Intel built its next-generation chips.

Megavirus was found off the coast of Las Cruces, central Chile. It was recovered as part of a general trawl in the ocean for biology of interest.

My trawls for such biology take place closer to home.

"This is a new way of doing virology," said Prof Claverie.

If there is one thing the world needs more of...

"Previously, we only discovered viruses because they caused disease in humans, or animals and plants. But now we are initiating what might be called environmental virology and we are looking for viruses everywhere.

If you look, ye shall find...

"You just go to lakes, seas and oceans and pick up the water, and then you filter it, and try to rescue the virus by co-cultivating it with some potential host."


You try to rescue the virus. With some people it's donkeys, with some people it's viruses.

More generally, there is interest in ocean viruses because they have a major influence on populations of plankton, the microscopic organisms that form the base of many marine food chains. And when they kill plankton, viruses are also helping to regulate the planet's geochemical cycles as the dead organisms sink into the deep, locking away their carbon for aeons.

I am interested in them for other reasons, myself.

Prof Claverie said the megavirus would not be hazardous to humans.

He would.

1 comment:

Marie said...

Do you think the previous fattest virus, Mimivirus, was named after somebody's ex-girlfriend?